Paris-Toulouse: a daily shuttle connects Paris to Toulouse in 1 hour and 10 minutes every 30 minutes.

38 regular flights, including 24 international flights (20 in Europe).
16 daily flights between Toulouse and the main provincial towns and cities.
20 daily flights between Toulouse and the main European capitals.
And many other international flights...

International Airport of Toulouse Blagnac located 15 minutes from the City centre (5th largest French airport for passenger traffic and the largest provincial airport for freight).
http://www.toulouse.airport.fr/

Toulouse has a direct motorway link with the main capitals of Northern and Southern Europe.

Paris-Bordeaux-Montpellier motorway network at the junction of:

A62 motorways (to Bordeaux)
A20 motorways (to Paris, via Montauban and Limoges)
A61 motorways (to Montpellier and Barcelona)
A64 motorways (Foix, Lourdes, Bayonne, San Sebastian)
A66 motorways (Pamiers, Foix, Andorra)
A68 motorways (to Albi and Lyon)
A75 motorways (Clermont-Ferrand, Béziers via the Millau Viaduct)

Road map

The Toulouse Matabiau SNCF train station

Toulouse is 5 hours and 30 minutes from Paris by fast train, 2 hours from Montpellier and 2 hours from Bordeaux

http://www.sncf.com/